PTCB Certified Pharmacy Technician (PTCE)MedicationsMedium
A patient calls the pharmacy asking for advice on how to take their new prescription for 'alendronate 70 mg, take 1 tablet by mouth once weekly'. Which of the following instructions is crucial for the technician to reinforce to ensure proper absorption and minimize esophageal irritation?
- ATake at bedtime with a small snack.
- BCrush the tablet and mix with applesauce for easier swallowing.
- CTake with a full glass of plain water at least 30 minutes before the first food or drink of the day.
- DTake with food to prevent stomach upset.
Show answer & explanationAnswer & explanation
Correct answer: C. Take with a full glass of plain water at least 30 minutes before the first food or drink of the day.
Alendronate must be taken with a full glass of plain water at least 30 minutes before any food, drink, or other medications to ensure adequate absorption and prevent severe esophageal irritation. The patient must also remain upright for at least 30 minutes after taking it.
Why the other options are wrong
- A. Taking alendronate at bedtime or lying down increases the risk of esophageal irritation.
- B. Crushing alendronate can increase the risk of esophageal irritation and alter its release.
- D. Taking alendronate with food significantly reduces absorption.
Alendronate Administration
Alendronate is a bisphosphonate used to treat osteoporosis. Proper administration is vital to maximize absorption and prevent severe esophageal adverse effects.
- Take with a full glass of plain water (6-8 oz).
- Take at least 30 minutes before the first food, drink, or medication of the day.
- Remain upright for at least 30 minutes after taking the dose.
- Do not chew, crush, or suck on the tablet.
Memory trick: Alendronate: Water First, Upright Always!