PTCB Certified Pharmacy Technician (PTCE)MedicationsMedium
A pharmacy technician is verifying a prescription for 'potassium chloride extended-release 20 mEq daily.' The patient asks if they can crush the tablet and mix it with applesauce to make it easier to swallow. What is the MOST appropriate advice the technician should provide?
- AOnly half the tablet can be crushed, and the other half swallowed whole.
- BYes, it is safe to crush the tablet and mix it with applesauce.
- CIt is acceptable to crush the tablet, but only if mixed with water, not applesauce.
- DNo, crushing the tablet can lead to a rapid release of potassium and cause adverse effects.
Show answer & explanationAnswer & explanation
Correct answer: D. No, crushing the tablet can lead to a rapid release of potassium and cause adverse effects.
Extended-release formulations are designed to release medication slowly over time. Crushing these tablets destroys the controlled-release mechanism, leading to a rapid dose dump which can cause dangerously high potassium levels (hyperkalemia) and potential cardiac issues.
Why the other options are wrong
- A. Altering extended-release tablets by crushing any portion is generally contraindicated.
- B. This is incorrect and potentially dangerous due to dose dumping.
- C. The issue is crushing the extended-release mechanism, not the food vehicle.
Extended-Release (ER) Formulations
Medication dosage forms designed to release the active ingredient slowly over an extended period, maintaining consistent drug levels.
- Should not be crushed, chewed, or cut.
- Prevents rapid dose dumping.
- Ensures prolonged therapeutic effect.
Memory trick: ER is for Easing Release, not Rushing Ruin.