MCAT® ExamBiological and Biochemical Foundations of Living SystemsMedium

A scientist is investigating a newly discovered bacterium that thrives in extremely hot, acidic environments. Analysis of its cellular components reveals specialized membrane lipids with hydrocarbon chains linked to glycerol by ether bonds, and a cell wall composed of pseudopeptidoglycan. Based on these characteristics, to which domain of life does this organism most likely belong?

  1. AFungi
  2. BBacteria
  3. CArchaea
  4. DEukarya
Show answer & explanation

Correct answer: C. Archaea

The presence of ether-linked membrane lipids and pseudopeptidoglycan in the cell wall are hallmark characteristics of Archaea, which are known for inhabiting extreme environments (extremophiles).

Why the other options are wrong

  • A. Fungi are eukaryotes, having ester-linked lipids and chitin cell walls.
  • B. Bacteria typically have ester-linked membrane lipids and cell walls made of peptidoglycan.
  • D. Eukarya have ester-linked lipids and diverse cell wall compositions (e.g., cellulose in plants, chitin in fungi) or lack cell walls.

Characteristics of Archaea

Archaea are a domain of single-celled microorganisms that are prokaryotes, distinct from bacteria and eukaryotes, often thriving in extreme environments.

  • Membrane lipids have ether linkages (not ester linkages like Bacteria/Eukarya).
  • Cell walls may contain pseudopeptidoglycan or S-layers, but never peptidoglycan.
  • Many are extremophiles (thermophiles, halophiles, acidophiles).

Memory trick: Remember 'BAE' for the three domains.

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